A comparative study between diallylnortoxiferine and tubocurarine.

Diallylnortoxiferine and tubocurarine were compared clinically in 493 adult patients undergoing a variety of surgical procedures. Diallylnortoxiferine was found to be approximately twice as potent as tubocurarine. Equipotent doses produced neuromuscular block of the same degree and duration. The incidence of hypotension, its degree and its age distribution are equal. Hypotension occurred in both groups, and its incidence was higher in patients above 40 years, and in patients with an initial blood pressure above 150 mm Hg. Both relaxants are adequately reversed with a mixture of atropine 0.02 mg/kg and neostigmine 0.05 mg/kg, provided an overdose of the relaxant used is avoided.